Highly sensitive ProGRP antibody, a diagnostic tool for small cell lung cancer
Lung cancer
Lung cancer is a malignant tumor with the highest morbidity and mortality in the world. In the past 50 years, many countries have reported that the morbidity and mortality of lung cancer have increased significantly. The morbidity and mortality of lung cancer in men account for the first of all malignant tumors, and the incidence and mortality of lung cancer occupy the second place in women. .
Lung cancer is divided into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). CT screening can detect early non-small cell lung cancer (NSCLC), but it is not sensitive for screening early small cell lung cancer, and pathological diagnosis is often needed. Small cell lung cancer (SCLC) accounts for 20% to 25% of primary lung cancers; it has the characteristics of high malignancy, short doubling time, early and extensive metastasis, and sensitivity to chemotherapy. Most patients are diagnosed at an advanced stage and have a poor prognosis .
ProGRP
ProGRP is short for precursor gastrin-releasing peptide (GRP), a small neuropeptide (2.9 kDa) encoded by the GRP gene and mainly expressed in the nervous system and gastrointestinal tract. The GRP precursor consists of 148 amino acids and is cleaved to form GRP (AA 24-50) and ProGRP (AA 54-148). The half-life of ProGRP is longer than that of GRP, and it can be detected in serum or plasma samples, which can reflect the level of GRP to a certain extent. Clinically, ProGRP is an ideal serum tumor marker for the diagnosis of small cell lung cancer, with a sensitivity of 80% and a specificity of 97% for the diagnosis of lung cancer. When combined with nerve-specific enolase (NSE), the diagnostic efficiency can be further improved . For the Chinese population, the clinical reference range of ProGRP is 0-65 pg/ml.
Medix Biochemica ProGRP antibody
Medix Biochemica has launched two new ProGRP monoclonal antibodies, which are characterized by high sensitivity and wide linear range (<49 pg/ml~400 ng/ml).
Table 1. Antibody affinity constant test results
Figure 1A. Antigen detection results of antibody 13002+13001
Figure 1B. Antigen detection results of antibodies 13002+HM784 and 13001+HM785
